A structural, epidemiological & genetic overview of Klebsiella pneumoniae carbapenemases (KPCs)
نویسندگان
چکیده
منابع مشابه
A structural, epidemiological & genetic overview of Klebsiella pneumoniae carbapenemases (KPCs)
Klebsiella pneumoniae carbapenemases (KPCs) are plasmid encoded carbapenem hydrolyzing enzymes which have the potential to spread widely through gene transfer. The instability of upstream region of blaKPC accelerates emergence of different isoforms. Routine antibiotic susceptibility testing failed to detect KPC producers and some commercial kits have been launched for early identification of KP...
متن کاملDetection and treatment options for Klebsiella pneumoniae carbapenemases (KPCs): an emerging cause of multidrug-resistant infection.
Bacteria producing Klebsiella pneumoniae carbapenemases (KPCs) are rapidly emerging as a cause of multidrug-resistant infections worldwide. Bacterial isolates harbouring these enzymes are capable of hydrolysing a broad spectrum of beta-lactams including the penicillins, cephalosporins, carbapenems and monobactam. Detection of isolates harbouring carbapenemases can be inconsistent using automate...
متن کاملOverview of the epidemiology and the threat of Klebsiella pneumoniae carbapenemases (KPC) resistance
Klebsiella pneumoniae carbapenemases (KPCs) confer resistance to nearly all β-lactams. This broad-spectrum drug resistance mechanism has rapidly spread in the United States and is reportedly increasing elsewhere in the world. Thus, the emergence of KPC resistance is a major threat to global health. This article reviews the epidemiology and provides an overview of the dissemination of KPC-produc...
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Objective(s): Infections due to carbapenemase-producing Klebsiella pneumoniae are associated with high morbidity and mortality. In this study, we report a hospital outbreak due to co-producing OXA-48 and NDM-1 K. pneumoniae clone. The aim of the study is to investigate the clonal relationship of strains, risk factors of outbreak and infection control measures.<em...
متن کاملThe spread of Klebsiella pneumoniae carbapenemases: a tale of strains, plasmids, and transposons.
Carbapenemases are a large and diverse family of microbial enzymes that hydrolyze not only carbapenems but also other b-lactams, with the occasional exception of monobactams, such as aztreonam. For clinicians, the nomenclature of carbapenemases, like that of other b-lactamases, is confusing. In keeping with other b-lactamases, carbapenemases can be classified on the basis of function or structu...
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ژورنال
عنوان ژورنال: Indian Journal of Medical Research
سال: 2016
ISSN: 0971-5916
DOI: 10.4103/0971-5916.193279